Ketamine "helped me get my life back," says James , who suffers from a variant of bipolar disorder called “fear of harm”. While the National Institutes of Health and many other research institutions have shown that IV ketamine can relieve depression, more research continues to mount showing ketamine administered by various methods, IV, sublingual and nasal, to be effective in treating many mental health disorders such as bipolar, anxiety and ocd. "I think it's actually one of the biggest advances in psychiatry in a very long time," says Dr. Martin Teicher, an associate professor of psychiatry at Harvard Medical School and director of the Developmental Biopsychiatry Research Program at McLean Hospital.